输入fasta格式的MSA序列(
):
>UrCas13d-HA -----------MAKKNKMKPRELREAQKKARQL--KAAEINNNAAPA--IAAMPAAEVIA PAAEKKKSSVKAAGMKSILV---SENKMYITSFGKGNSAVLEYEVDN-------NDYNQT QLSSKDNSNIQLGGVNEVNITFSSKHGFESGVEINT--SNPTHR--SGESSP--VRGDML GLKSELEKRFFGKTF-DDNIHIQLIYNILDIEKILAVYVTNIVYALNNMLGVKGSE--SH DDFIGYLSTNNIYDVFIDPD-NSSLSDDKKANVRKSLSKFN--ALLKTKRLGYFG--LE- EPKTKDNRVSQAYKKR------VYHMLAIVGQIRQCVFHDKSG----AKRFDLYSFINNI DPEYRDTLDYLVEERLKSINKDFIEDNKVNISLLIDMMKGYEADDIIRL---YYDFIVLK SQKNLGFSIKKLREKMLDEYGF-RFKDKQYDSVRSKMYKLMDFLLFCNYYRNDIAAGESL VRKLRFSMTDDEKEGIYADEAAKLWGKFRNDFE-NIADHMNGDVIK-ELGKADMDFDEKI LD----------------SEKKNASDLLYFSKMIYMLTYFLDGKEINDLLTTLISKFDNI KEFLKIMKSSAVDVECELTAGYKLFND---SQRITNELFIVKNIASMRKPAASAKLTMFR DALTILGIDD-----KITDDRISG-ILKLKEKG------KGIH-----GLRNFITNNVIE SSRFVYLIKYANAQKIREVAKNEKVVMFVLGGIPDTQIERYYKSCVEFPDMNSSLGVKRS ELARMIKNISFDDFKNVK-----QQAKGRENVAKERAKAVIGLYLTVMYLLVKNLVNVNA RYVIAIHCLERDFGLYKEIIPELASKNLKN---DYRILSQTLCELCD------------- ------KSPNLFLKK---NERLRKCVEVDINNAD--------SS-----MTRKYRNCIAH LTVVRELKEYIGDI-------CTVDSYFSIYHYVMQRCITKRENDTKQEEKIKYE--DDL LKNHGYT-------KDFVKALNSPFGYNIPRFKNLSIEQLFDR--NEYLTEK--YPYDVP D---------YA-- >dUrCas13d-HA -----------MAKKNKMKPRELREAQKKARQL--KAAEINNNAAPA--IAAMPAAEVIA PAAEKKKSSVKAAGMKSILV---SENKMYITSFGKGNSAVLEYEVDN-------NDYNQT QLSSKDNSNIQLGGVNEVNITFSSKHGFESGVEINT--SNPTHR--SGESSP--VRGDML GLKSELEKRFFGKTF-DDNIHIQLIYNILDIEKILAVYVTNIVYALNNMLGVKGSE--SH DDFIGYLSTNNIYDVFIDPD-NSSLSDDKKANVRKSLSKFN--ALLKTKRLGYFG--LE- EPKTKDNRVSQAYKKR------VYHMLAIVGQIAQCVFADKSG----AKRFDLYSFINNI DPEYRDTLDYLVEERLKSINKDFIEDNKVNISLLIDMMKGYEADDIIRL---YYDFIVLK SQKNLGFSIKKLREKMLDEYGF-RFKDKQYDSVRSKMYKLMDFLLFCNYYRNDIAAGESL VRKLRFSMTDDEKEGIYADEAAKLWGKFRNDFE-NIADHMNGDVIK-ELGKADMDFDEKI LD----------------SEKKNASDLLYFSKMIYMLTYFLDGKEINDLLTTLISKFDNI KEFLKIMKSSAVDVECELTAGYKLFND---SQRITNELFIVKNIASMRKPAASAKLTMFR DALTILGIDD-----KITDDRISG-ILKLKEKG------KGIH-----GLRNFITNNVIE SSRFVYLIKYANAQKIREVAKNEKVVMFVLGGIPDTQIERYYKSCVEFPDMNSSLGVKRS ELARMIKNISFDDFKNVK-----QQAKGRENVAKERAKAVIGLYLTVMYLLVKNLVNVNA RYVIAIHCLERDFGLYKEIIPELASKNLKN---DYRILSQTLCELCD------------- ------KSPNLFLKK---NERLRKCVEVDINNAD--------SS-----MTRKYANCIAA LTVVRELKEYIGDI-------CTVDSYFSIYHYVMQRCITKRENDTKQEEKIKYE--DDL LKNHGYT-------KDFVKALNSPFGYNIPRFKNLSIEQLFDR--NEYLTEK--YPYDVP D---------YA-- >NLS-UrCas13d-NLS-HA MSPKKKRKVEASAKKNKMKPRELREAQKKARQL--KAAEINNNAAPA--IAAMPAAEVIA PAAEKKKSSVKAAGMKSILV---SENKMYITSFGKGNSAVLEYEVDN-------NDYNQT QLSSKDNSNIQLGGVNEVNITFSSKHGFESGVEINT--SNPTHR--SGESSP--VRGDML GLKSELEKRFFGKTF-DDNIHIQLIYNILDIEKILAVYVTNIVYALNNMLGVKGSE--SH DDFIGYLSTNNIYDVFIDPD-NSSLSDDKKANVRKSLSKFN--ALLKTKRLGYFG--LE- EPKTKDNRVSQAYKKR------VYHMLAIVGQIRQCVFHDKSG----AKRFDLYSFINNI DPEYRDTLDYLVEERLKSINKDFIEDNKVNISLLIDMMKGYEADDIIRL---YYDFIVLK SQKNLGFSIKKLREKMLDEYGF-RFKDKQYDSVRSKMYKLMDFLLFCNYYRNDIAAGESL VRKLRFSMTDDEKEGIYADEAAKLWGKFRNDFE-NIADHMNGDVIK-ELGKADMDFDEKI LD----------------SEKKNASDLLYFSKMIYMLTYFLDGKEINDLLTTLISKFDNI KEFLKIMKSSAVDVECELTAGYKLFND---SQRITNELFIVKNIASMRKPAASAKLTMFR DALTILGIDD-----KITDDRISG-ILKLKEKG------KGIH-----GLRNFITNNVIE SSRFVYLIKYANAQKIREVAKNEKVVMFVLGGIPDTQIERYYKSCVEFPDMNSSLGVKRS ELARMIKNISFDDFKNVK-----QQAKGRENVAKERAKAVIGLYLTVMYLLVKNLVNVNA RYVIAIHCLERDFGLYKEIIPELASKNLKN---DYRILSQTLCELCD------------- ------KSPNLFLKK---NERLRKCVEVDINNAD--------SS-----MTRKYRNCIAH LTVVRELKEYIGDI-------CTVDSYFSIYHYVMQRCITKRENDTKQEEKIKYE--DDL LKNHGYT-------KDFVKALNSPFGYNIPRFKNLSIEQLFDR--NEYLTEKGSGPKKKR K---------VAAA >NLS-dUrCas13d-NLS-HA MSPKKKRKVEASAKKNKMKPRELREAQKKARQL--KAAEINNNAAPA--IAAMPAAEVIA PAAEKKKSSVKAAGMKSILV---SENKMYITSFGKGNSAVLEYEVDN-------NDYNQT QLSSKDNSNIQLGGVNEVNITFSSKHGFESGVEINT--SNPTHR--SGESSP--VRGDML GLKSELEKRFFGKTF-DDNIHIQLIYNILDIEKILAVYVTNIVYALNNMLGVKGSE--SH DDFIGYLSTNNIYDVFIDPD-NSSLSDDKKANVRKSLSKFN--ALLKTKRLGYFG--LE- EPKTKDNRVSQAYKKR------VYHMLAIVGQIAQCVFADKSG----AKRFDLYSFINNI DPEYRDTLDYLVEERLKSINKDFIEDNKVNISLLIDMMKGYEADDIIRL---YYDFIVLK SQKNLGFSIKKLREKMLDEYGF-RFKDKQYDSVRSKMYKLMDFLLFCNYYRNDIAAGESL VRKLRFSMTDDEKEGIYADEAAKLWGKFRNDFE-NIADHMNGDVIK-ELGKADMDFDEKI LD----------------SEKKNASDLLYFSKMIYMLTYFLDGKEINDLLTTLISKFDNI KEFLKIMKSSAVDVECELTAGYKLFND---SQRITNELFIVKNIASMRKPAASAKLTMFR DALTILGIDD-----KITDDRISG-ILKLKEKG------KGIH-----GLRNFITNNVIE SSRFVYLIKYANAQKIREVAKNEKVVMFVLGGIPDTQIERYYKSCVEFPDMNSSLGVKRS ELARMIKNISFDDFKNVK-----QQAKGRENVAKERAKAVIGLYLTVMYLLVKNLVNVNA RYVIAIHCLERDFGLYKEIIPELASKNLKN---DYRILSQTLCELCD------------- ------KSPNLFLKK---NERLRKCVEVDINNAD--------SS-----MTRKYANCIAA LTVVRELKEYIGDI-------CTVDSYFSIYHYVMQRCITKRENDTKQEEKIKYE--DDL LKNHGYT-------KDFVKALNSPFGYNIPRFKNLSIEQLFDR--NEYLTEKGSGPKKKR K---------VAAA >P1E0Cas13d-HA M----------------------------EREV----------KKPP------------- -----KKSLAKAAGLKSTFVISPQEKELAMTAFGRGNDALLQKRIVDGVVRDVAGEKQQF QVQRQDESRFRLQNSRLADRT------------VTA--DDPLHRAETPRRQPLGAGMDQL RRKAILEQKYFGRTF-DDNIHIQLIYNILDIHKMLAVPANHIVHTLNLLGG------YGE TDFVGMLPAGLPYD---------KLRVVKKKNGDTVDIKADIAAYAKRPQLAYLG--AAF YDVTPGKSKRDAARGRVKREQDVYAILSLMSLLRQFCAHDSVRIWGQNTTAALYH-LQAL PQDMKDLLDDGWRRALGGVNDHFLDTNKVNLLTLFEYYGAETKQARVALTQDFYRFVVLK EQKNMGFSLRRLREELLKLPDAAYLTGQEYDSVRQKLYMLLDFLLCRLYAQERADRCEEL VSALRCALSDEEKDTVYQAEAAALWQALGDTLR--------RKLLPLLKGKKLQDKDKKK SDELGLSRDVLDGVLFRPAQQGSRANADYFCRLMHLSTWFMDGKEINTLLTTLISKLENI DSLRSVLES--MGLAYSFVPAYAMFDH---SRYIAGQLRVVNNIARMRKPAIGAKREMYR AAVVLLGVDSPEAAAAITDDLLQI-------DPETGKVRPRSDSARDTGLRNFIANNVVE SRRFTYLLRYMTPEQARVLAQNEKLIAFVLSTVPDTQLERYCRTCGR-EDIT-GRPAQIR YLTAQIMGVRYESFTDVE-----QRGRG-DNPKKERYKALIGLYLTVLYLAVKNMVNCNA RYVIAFYCRDRDTALYQK---EVCWYDLEE---DKKSGKQRQVEDYT------------- ------ALTRYFVSQGYLNRHACGYLRSNMNGIS--------NS-----LLTAYRNAVDH LNAIPPLGSLCRDI-------GRVDSYFALYHYAVQQYLNGRYYRKTPREQELF---AAM AQHRTWC-------SDLVKALNTPFGYNLARYKNLSIDGLFDREGDHVVRED--GEKPAE -------------- >NLS-P1E0Cas13d-NLS-HA M-----------------SPKKKRKVEASEREV----------KKPP------------- -----KKSLAKAAGLKSTFVISPQEKELAMTAFGRGNDALLQKRIVDGVVRDVAGEKQQF QVQRQDESRFRLQNSRLADRT------------VTA--DDPLHRAETPRRQPLGAGMDQL RRKAILEQKYFGRTF-DDNIHIQLIYNILDIHKMLAVPANHIVHTLNLLGG------YGE TDFVGMLPAGLPYD---------KLRVVKKKNGDTVDIKADIAAYAKRPQLAYLG--AAF YDVTPGKSKRDAARGRVKREQDVYAILSLMSLLRQFCAHDSVRIWGQNTTAALYH-LQAL PQDMKDLLDDGWRRALGGVNDHFLDTNKVNLLTLFEYYGAETKQARVALTQDFYRFVVLK EQKNMGFSLRRLREELLKLPDAAYLTGQEYDSVRQKLYMLLDFLLCRLYAQERADRCEEL VSALRCALSDEEKDTVYQAEAAALWQALGDTLR--------RKLLPLLKGKKLQDKDKKK SDELGLSRDVLDGVLFRPAQQGSRANADYFCRLMHLSTWFMDGKEINTLLTTLISKLENI DSLRSVLES--MGLAYSFVPAYAMFDH---SRYIAGQLRVVNNIARMRKPAIGAKREMYR AAVVLLGVDSPEAAAAITDDLLQI-------DPETGKVRPRSDSARDTGLRNFIANNVVE SRRFTYLLRYMTPEQARVLAQNEKLIAFVLSTVPDTQLERYCRTCGR-EDIT-GRPAQIR YLTAQIMGVRYESFTDVE-----QRGRG-DNPKKERYKALIGLYLTVLYLAVKNMVNCNA RYVIAFYCRDRDTALYQK---EVCWYDLEE---DKKSGKQRQVEDYT------------- ------ALTRYFVSQGYLNRHACGYLRSNMNGIS--------NS-----LLTAYRNAVDH LNAIPPLGSLCRDI-------GRVDSYFALYHYAVQQYLNGRYYRKTPREQELF---AAM AQHRTWC-------SDLVKALNTPFGYNLARYKNLSIDGLFDREGDHVVRED--GEKPAE G-SGPKKKRKVAAA >RffCas13d-HA M-------------KKKMSLREKREAEKQAKKAAYSAASKNTDSKPAEKKAETPKPAEII SDNSRNKTAVKAAGLKSTII---SGDKLYMTSFGKGNAAVIEQKIDI-------NDYSFS AM--KDTPSLEVDKAESKEISFSSHHPFVKNDKLTT--YNPLYGGKDNPEKP--VGRDML GLKDKLEERYFGCTF-NDNLHIQIIYNILDIEKILAVHSANITTALDHMVD-EDDEKYLN SDYIGYMNTINTYDVFMDPSKNSSLSPKDRKNIDNSRAKFE--KLLSTKRLGYFG--FDY DANGKDKKKNEEIKKR------LYHLTAFAGQLRQWSFHSAGN----YPRTWLYK-LDSL DKEYLDTLDHYFDKRFNDINDDFVTKNATNLYILKEVFPEANFKDIADL---YYDFIVIK SHKNMGFSIKKLREKMLECDGADRIKEQDMDSVRSKLYKLIDFCIF-KYYHEFPELSEKN VDILRAAVSDTKKDNLYSDEAARLWSIFKEKFL-GFCDKI---VVW-VTGEHEKDITSVI DK----------------DAYRNRSNVSYFSKLMYAMCFFLDGKEINDLLTTLINKFDNI ANQIKTAKE--LGINTAFVKNYDFFNH---SEKYVDELNIVKNIARMKKPSSNAKKAMYH DALTILGIPEDMDE-KALDEELDL-ILEKKTDPVTGKPLKGKN-----PLRNFIANNVIE NSRFIYLIKFCNPENVRKIVNNTKVTEFVLKRIPDAQIERYYKSCTD-SEMNPPTEKKIT ELAGKLKDMNFGNFRNVR-----QSAK--ENMEKERFKAVIGLYLTVVYRVVKNLVDVNS RYIMAFHSLERDSQLY--------NVSVDN---DYLALTDTLVKEGD------------- ------NSRSRYLAG---NKRLRDCVKQDIDNAKKWFVSDKYNS-----IT-KYRNNVAH LTAVRNCAEFIGDI-------TKIDSYFALYHYLIQRQLAKGLDHERSGFDRNYPQYAPL FKWHTYV-------KDVVKALNAPFGYNIPRFKNLSIDALFDR--NEIKKND--GEKKSD D------------- >NLS-RffCas13d-NLS-HA MSPKKKRKV--EASKKKMSLREKREAEKQAKKAAYSAASKNTDSKPAEKKAETPKPAEII SDNSRNKTAVKAAGLKSTII---SGDKLYMTSFGKGNAAVIEQKIDI-------NDYSFS AM--KDTPSLEVDKAESKEISFSSHHPFVKNDKLTT--YNPLYGGKDNPEKP--VGRDML GLKDKLEERYFGCTF-NDNLHIQIIYNILDIEKILAVHSANITTALDHMVD-EDDEKYLN SDYIGYMNTINTYDVFMDPSKNSSLSPKDRKNIDNSRAKFE--KLLSTKRLGYFG--FDY DANGKDKKKNEEIKKR------LYHLTAFAGQLRQWSFHSAGN----YPRTWLYK-LDSL DKEYLDTLDHYFDKRFNDINDDFVTKNATNLYILKEVFPEANFKDIADL---YYDFIVIK SHKNMGFSIKKLREKMLECDGADRIKEQDMDSVRSKLYKLIDFCIF-KYYHEFPELSEKN VDILRAAVSDTKKDNLYSDEAARLWSIFKEKFL-GFCDKI---VVW-VTGEHEKDITSVI DK----------------DAYRNRSNVSYFSKLMYAMCFFLDGKEINDLLTTLINKFDNI ANQIKTAKE--LGINTAFVKNYDFFNH---SEKYVDELNIVKNIARMKKPSSNAKKAMYH DALTILGIPEDMDE-KALDEELDL-ILEKKTDPVTGKPLKGKN-----PLRNFIANNVIE NSRFIYLIKFCNPENVRKIVNNTKVTEFVLKRIPDAQIERYYKSCTD-SEMNPPTEKKIT ELAGKLKDMNFGNFRNVR-----QSAK--ENMEKERFKAVIGLYLTVVYRVVKNLVDVNS RYIMAFHSLERDSQLY--------NVSVDN---DYLALTDTLVKEGD------------- ------NSRSRYLAG---NKRLRDCVKQDIDNAKKWFVSDKYNS-----IT-KYRNNVAH LTAVRNCAEFIGDI-------TKIDSYFALYHYLIQRQLAKGLDHERSGFDRNYPQYAPL FKWHTYV-------KDVVKALNAPFGYNIPRFKNLSIDALFDR--NEIKKND--GEKKSD DGSGPKKKRKVAAA >UrCas13d -----------MAKKNKMKPRELREAQKKARQL--KAAEINNNAAPA--IAAMPAAEVIA PVAEKKKSSVKAAGMKSILV---SENKMYITSFGKGNSAVLEYEVDN-------NDYNKT QLSSKDNSNIELGDVNEVNITFSSKHGFGSGVEINT--SNPTHR--SGESSP--VRGDML GLKSELEKRFFGKTF-DDNIHIQLIYNILDIEKILAVYVTNIVYALNNMLGIKDSE--SY DDFMGYLSARNTYEVFTHPD-KSNLSDKVKGNIKKSLSKFN--DLLKTKRLGYFG--LE- EPKTKDTRASEAYKKR------VYHMLAIVGQIRQCVFHDKSG----AKRFDLYSFINNI DPEYRDTLDYLVEERLKSINKDFIEGNKVNISLLIDMMKGYEADDIIRL---YYDFIVLK SQKNLGFSIKKLREKMLEEYGF-RFKDKQYDSVRSKMYKLMDFLLFCNYYRNDVAAGEAL VRKLRFSMTDDEKEGIYADEAAKLWGKFRNDFE-NIADHMNGDVIK-ELGKADMDFDEKI LD----------------SEKKNASDLLYFSKMIYMLTYFLDGKEINDLLTTLISKFDNI KEFLKIMKSSAVDVECELTAGYKLFND---SQRITNELFIVKNIASMRKPAASAKLTMFR DALTILGIDD-----NITDDRISE-ILKLKEKG------KGIH-----GLRNFITNNVIE SSRFVYLIKYANAQKIREVAKNEKVVMFVLGGIPDTQIERYYKSCVEFPDMNSSLEAKRS ELARMIKNISFDDFKNVK-----QQAKGRENVAKERAKAVIGLYLTVMYLLVKNLVNVNA RYVIAIHCLERDFGLYKEIIPELASKNLKN---DYRILSQTLCELCDDRN---------- ------ESSNLFLKK---NKRLRKCVEVDINNAD--------SS-----MTRKYRNCIAH LTVVRELKEYIGDI-------RTVDSYFSIYHYVMQRCITKRGDDTKQEEKIKYE--DDL LKNHGYT-------KDFVKALNSPFGYNIPRFKNLSIEQLFDR--NEYLTEK-------- -------------- >cas13_RBI_RS12820.cas13d_WP_041337480.1 -----------MAKKNKMKPRELREAQKKARQL--KAAEINNNAVPA--IAAMPAAEAAA PAAEKKKSSVKAAGMKSILV---SENKMYITSFGKGNSAVLEYEVDN-------NDYNKT QLSSKDNSNIELCDVGKVNITFSSRRGFESGVEINT--SNPTHR--SGESSS--VRGDML GLKSELEKRFFGKNF-DDNIHIQLIYNILDIEKILAVYVTNIVYALNNMLG-EGDE--SN YDFMGYLSTFNTYKVFTNPN-GSTLSDDKKENIRKSLSKFN--ALLKTKRLGYFG--LE- EPKTKDTRASEAYKKR------VYHMLAIVGQIRQCVFHDKSG----AKRFDLYSFINNI DPEYRETLDYLVDERFDSINKGFIQGNKVNISLLIDMMKGYEADDIIRL---YYDFIVLK SQKNLGFSIKKLREKMLDEYGF-RFKDKQYDSVRSKMYKLMDFLLFCNYYRNDIAAGESL VRKLRFSMTDDEKEGIYADEAAKLWGKFRNDFE-NIADHMNGDVIK-ELGKADMDFDEKI LD----------------SEKKNASDLLYFSKMIYMLTYFLDGKEINDLLTTLISKFDNI KEFLKIMKSSAVDVECELTAGYKLFND---SQRITNELFIVKNIASMRKPAASAKLTMFR DALTILGIDD-----KITDDRISE-ILKLKEKG------KGIH-----GLRNFITNNVIE SSRFVYLIKYANAQKIREVAKNEKVVMFVLGGIPDTQIERYYKSCVEFPDMNSSLGVKRS ELARMIKNISFDDFKNVK-----QQAKGRENVAKERAKAVIGLYLTVMYLLVKNLVNVNA RYVIAIHCLERDFGLYKEIIPELASKNLKN---DYRILSQTLCELCD------------- ------KSPNLFLKK---NERLRKCVEVDINNAD--------SS-----MTRKYRNCIAH LTVVRELKEYIGDI-------CTVDSYFSIYHYVMQRCITKRENDTKQEEKIKYE--DDL LKNHGYT-------KDFVKALNSPFGYNIPRFKNLSIEQLFDR--NEYLTEK-------- --------------
按照序列名称进行排序:
对序列名称做关键字匹配:
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搜索序列motif:
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